Insulin-degrading enzyme: A link between Alzheimer’s and type 2 diabetes mellitus
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive InfoField | Value | |
Creator |
Haque, Rizwanul
Nazir, Aamir |
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Date |
2015-03-23T08:16:07Z
2015-03-23T08:16:07Z 2014 |
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Identifier |
CNS & Neurological Disorders - Drug Targets, 2014, 13(2), 259-64.
http://hdl.handle.net/123456789/1439 |
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Description |
Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s Disease (AD). Recent studies provide inkling for the use of IDE as a potential target, hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes and Alzheimer’s disease and the approaches, that make IDE a potential target, are discussed.
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200242 bytes
application/pdf |
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Language |
en
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Relation |
CSIR-CDRI Communication No. 8881
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Subject |
IDE
Alzheimer’s disease Type 2 Diabetes Caenorhabditis elegans |
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Title |
Insulin-degrading enzyme: A link between Alzheimer’s and type 2 diabetes mellitus
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Type |
Article
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