Chemically modified flexible strips as electrochemical biosensors
IR@CECRI: CSIR-Central Electrochemical Research Institute, Karaikudi
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Title |
Chemically modified flexible strips as
electrochemical biosensors
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Creator |
Raju, T.
Ganesh, V. |
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Subject |
Electrochemical Sensors
Electrodics and Electrocatalysis |
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Description |
A flexible and disposable strip sensor for non-enzymatic glucose detection is demonstrated in this work.
The strips are prepared by using chemical modification processes followed by a simple electroless
deposition of copper. Essentially, polyester overhead projector (OHP) transparent films are modified with
a monolayer of 3-aminopropyltrimethoxysilane (APTMS) and polyaniline (PANI) conducting polymer.
Later, nanostructured copper is deposited onto this modified film. Scanning electron microscope (SEM)
and X-ray diffraction (XRD) studies are used for the structural, morphological and crystallinity
characterization of the modified films. Electrochemical techniques, namely cyclic voltammetry (CV) and
chronoamperometry (CA), are employed for the non-enzymatic detection of glucose. These studies
clearly reveal the formation of homogeneous, close-packed spherical Cu particles converged into
uniform film that exhibits a good catalytic activity towards the oxidation of glucose. The Cu/PANI/
APTMS/OHP sensor displays a remarkable enhancement in the oxidation current density, a very high
sensitivity value of 2.8456 mA cm�2 per mM, and a linear concentration range from 100 mM to 6.5 mM
associated with glucose detection. Detection limit is estimated to be 5 mM and the response time of the
sensor is determined to be less than 5 s. For comparison, similar studies are performed without PANI,
namely Cu/APTMS/OHP films for glucose detection. In this case, a sensitivity value of 2.4457 mA cm�2
per mM and a linear concentration range of 100 mM–3 mM are estimated. The higher performance
characteristics observed in the case of Cu/PANI/APTMS/OHP are attributed to the synergistic effects of
the conducting polymer acting as an electron facilitator and the nanostructured Cu films. These
disposable, flexible and low-cost strip sensors have also been applied to the detection of glucose in
clinical blood serum samples and the results obtained agree very well with the actual glucose level
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Publisher |
The Royal Society of Chemistry
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Date |
2014
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Type |
Article
PeerReviewed |
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Format |
application/pdf
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Identifier |
http://cecri.csircentral.net/3081/1/023-2014.pdf
Raju, T. and Ganesh, V. (2014) Chemically modified flexible strips as electrochemical biosensors. Analyst, 139. pp. 4661-4672. |
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Relation |
http://www.rsc.org/analyst
http://cecri.csircentral.net/3081/ |
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