Protective effect of coenzyme Q10 in simvastatin and gemfibrozil induced rhabdomyolysis in rats
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Farswan, Mamta
Rathod, S P Upaganlawar, A B Semwal, Arvind |
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| Date |
2013-11-11T10:43:55Z
2013-11-11T10:43:55Z 2005-10 |
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| Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/23248 |
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| Description |
845-848
Administration of simvastatin (80 mg/kg, po. evening dose) and gemfibrozil (600 mg/kg, po twice) for 30 days produced significant decrease in the level of reduced glutathione, superoxide dismutase, catalase and increase in the level of lipid peroxidation and various serum parameters (creatine phosphokinase, lactate dehydrogenase, serum glutamate oxaloacetate transaminase, creatinine, urea and blood urea nitrogen). This suggested involvement of oxidative stress in rhabdomyolysis. Increase in the level of reduced glutathione, superoxide dismutase, catalase and decrease in the level of lipid peroxidation and serum parameters after administration of antioxidant CoQ10 (10 mg/kg.ip) proved the protective effect of CoQ 10 in rhabdomyolysis. |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Relation |
<span style="font-size:12.0pt;line-height:115%; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:HI">Int Cl<sup>7</sup> A61P</span>
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJEB Vol.43(10) [October 2005]
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| Subject |
Antioxidant
Coenzyme Q10 Gemfibrozil Oxidative stress Prooxidant Rhabdomyolysis Simvastatin |
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| Title |
Protective effect of coenzyme Q10 in simvastatin and gemfibrozil induced rhabdomyolysis in rats
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| Type |
Article
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