Immunomodulatory active steroidal saponins from Asparagus racemosus
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
Immunomodulatory active steroidal saponins from Asparagus
racemosus
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| Creator |
Sharma, Upendra
Kumar, Neeraj Singh , Bikram Munshi, Renuka K. Bhalerao, Supriya |
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| Subject |
Natural Product Chemistry
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| Description |
Asparagus racemosus is used in the Indian
traditional system of medicine for improving the general
state of health and stress-related immune disorders. Most of
the synthetic chemotherapeutic agents available today are
immunosuppressants and exert variety of side effects. To
overcome these undesired effects of chemotherapeutic
agents, botanical-based immunomodulators are often
employed as adjuvant therapy. In the present study,
immunomodulatory activity of two steroidal saponins
shatavaroside A (1) and shatavaroside B (2), isolated from
Asparagus racemosus, have been evaluated using polymorphonuclear
leucocyte function test. The activity was
further confirmed using more sensitive assays such as
nitroblue tetrazolium, nitrous oxide, and chemiluminescence
assays. Both steroidal saponins were found active at
nano concentration (5 ng/ml) and can act as potent
immunostimulants.
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/1322/1/105_Immunomodulatory.pdf
Sharma, Upendra and Kumar, Neeraj and Singh , Bikram and Munshi, Renuka K. and Bhalerao, Supriya (2013) Immunomodulatory active steroidal saponins from Asparagus racemosus. Journal of Medicinal Chemistry Research, 22. pp. 573-579. |
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| Relation |
http://ihbt.csircentral.net/1322/
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