Development of stevioside Pluronic-F-68 copolymer based PLA-nanoparticles as an antidiabetic nanomedicine
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
Development of stevioside Pluronic-F-68 copolymer based PLA-nanoparticles as
an antidiabetic nanomedicine
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| Creator |
Barwala,, Indu
Sood, Anil Sharma, Mohit Singh , Bikram Yadav, Subhash C. |
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| Subject |
Plant sciences
Plant Biotechnology |
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| Description |
Stevioside (FDA approved nontoxic natural non-caloric sweetener) has been reported to have very good
antidiabetic potential but its use as therapeutic drug is restricted in human due to its deprived intestinal
absorption and poor bioavailability. We have nano-bioconjugated this molecule on biodegradable
Pluronic-F-68 copolymer based PLA nanoparticles by nanoprecipitation method (spherical, size range
110–130 nm) to overcome deprived intestinal absorption and to enhance the bioavailability. The drug
loading calculated by the standard calibrated HPLC was 16.32
±
4% (w/w). The in vitro release study
showed the initial burst followed by the sustained release. The half release and complete release were
observed on 25
±
4 h and 200
±
10 h respectively. This newly formulated nanostevioside showed very
high potential to be used as antidiabetic nanomedicine for safe and effective use in vivo.
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/1319/1/100_Deveopment_of_stevioside.pdf
Barwala,, Indu and Sood, Anil and Sharma, Mohit and Singh , Bikram and Yadav, Subhash C. (2013) Development of stevioside Pluronic-F-68 copolymer based PLA-nanoparticles as an antidiabetic nanomedicine. Journal of Colloids and Surfaces B: Biointerfaces, 101. pp. 510-516. |
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| Relation |
http://ihbt.csircentral.net/1319/
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