Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
Synthesis of substituted amines and isoindolinones: catalytic reductive
amination using abundantly available AlCl3/PMHS
|
|
| Creator |
Kumar, Vishal
Sharma, Sushila Sharma, U Singh , Bikram Kumar, Neeraj |
|
| Subject |
Natural Product Chemistry
|
|
| Description |
AlCl3 has been employed for highly chemoselective reductive amination of carbonyl compounds in
ethanol using polymethylhydrosiloxane as an inexpensive, stable and safe reducing agent without an inert
atmosphere. A large range of functional groups such as nitro, carboxylic acid, acetyl, nitrile, halogen,
methoxy, alkene and heterocycles were well tolerated. AlCl3 also catalyzed tandem amination–amidation
of 2-carboxybenzaldehyde with different amines to afford N-substituted isoindolinones. The catalyst can
be recycled at least three times without any significant effect on activity and selectivity.
|
|
| Date |
2012
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://ihbt.csircentral.net/1234/1/38_Synthesis.pdf
Kumar, Vishal and Sharma, Sushila and Sharma, U and Singh , Bikram and Kumar, Neeraj (2012) Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS. Green Chmistry, 14. pp. 3410-3414. |
|
| Relation |
http://ihbt.csircentral.net/1234/
|
|