Conceptual approaches for lncRNA drug discovery and future strategies
IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New Delhi
View Archive Info| Field | Value | |
| Title |
Conceptual approaches for
lncRNA drug discovery and future
strategies
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| Creator |
Bhartiya, Deeksha
Kapoor, Shruti Jalali, Saakshi Sati, Satish Kaushik, Kriti Sachidanandan, Chetana Sivasubbu, Sridhar Scaria, Vinod |
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| Subject |
G1 Genome informatics (General)
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| Description |
Introduction: Long non-coding RNAs (lncRNAs) are a recently discovered class
of non-coding functional RNA which has attracted immense research interest.
The growing corpus of literature in the field provides ample evidence to
suggest the important role of lncRNAs as regulators in a wide spectrum of
biological processes. Recent evidence also suggests the role of lncRNAs in
the pathophysiology of disease processes.
Areas covered: The authors discuss a conceptual framework for understanding
lncRNA-mediated regulation as a function of its interaction with other biomo-
lecules in the cell. They summarize the mechanisms of the known functions of
lncRNAs in light of this conceptual framework, and suggest how this insight
could help in discovering novel targets for drug discovery. They also
argue how certain emerging technologies could be of immense utility,
both in discovering potential therapeutic targets as well as in further
For personal use only.
therapeutic development.
Expert opinion: The authors propose how the field could immensely benefit
from methodologies and technologies from six emerging fields in molecular
and computational biology. They also suggest a futuristic area of lncRNAs
design as a potential offshoot of synthetic biology, which would be an
attractive field, both for discovery of targets as well as a therapeutic strategy.
Keywords: artificial lncRNA, biomolecular interactions, cancer, comparative genomics,
DNAzyme, drug discovery, genomics, high-throughput screening, long non-coding RNA,
non-coding RNA, oligonucleotide delivery, small molecules, synthetic biology, systems biology,
transcriptome
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| Date |
2012-05-05
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://openaccess.igib.res.in/142/1/17460441%252E2012%252E682055.pdf
Bhartiya, Deeksha and Kapoor, Shruti and Jalali, Saakshi and Sati, Satish and Kaushik, Kriti and Sachidanandan, Chetana and Sivasubbu, Sridhar and Scaria, Vinod (2012) Conceptual approaches for lncRNA drug discovery and future strategies. Conceptual approaches for lncRNA drug discovery and future strategies, 10 (1517). pp. 1-10. ISSN 1746-0441 |
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| Relation |
http://openaccess.igib.res.in/142/
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