Potential G-quadruplexes in the human long non-coding transcriptome
IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New Delhi
View Archive Info| Field | Value | |
| Title |
Potential G-quadruplexes in the human long
non-coding transcriptome
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| Creator |
Jayaraj, Gopal Gunanathan
Pandey, Satyaprakash Scaria, Vinod Maiti, Souvik |
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| Subject |
G1 Genome informatics (General)
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| Description |
DNA G-quadruplexes are known as modulators of transcription. More recently G-quadruplexes, located in the untranslated regions of the mRNA of protein coding genes, have been described to negatively regulate gene expression at the post transcriptional/ translational levels. Here we describe the possibility of the existence of G-quadruplexes in non-coding RNA (ncRNA) and discuss their potential biological roles. Using an in house prediction tool (Quadfinder) we observe a significant occurrence and distribution of G-quadruplexes in ncRNA of various sizes. We also observe that most of non-coding RNAs harbouring these potential quadruplex motifs peak at the sizes ranging from 200-300 bases. More importantly we report enrichment for single and dinucleotide loops indicating a degree of high stability of these G-quadruplexes and their potential functions in vivo. Subsequent in vitro analyses of a subset of these sequences were performed which support our predictions.
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| Date |
2012-01-01
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://openaccess.igib.res.in/134/1/2011RNABIOL0146R.pdf
Jayaraj, Gopal Gunanathan and Pandey, Satyaprakash and Scaria, Vinod and Maiti, Souvik (2012) Potential G-quadruplexes in the human long non-coding transcriptome. Potential G-quadruplexes in the human long non-coding transcriptome, 9 (1). pp. 1-6. |
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| Relation |
http://openaccess.igib.res.in/134/
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