Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication
IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New DelhiView Archive Info
Human cellular microRNA hsa-miR-29a interferes with viral nef
protein expression and HIV-1 replication
Ahluwalia, Jasmine K
Khan, Sohrab Zafar
Brahmachari, Samir K.
G1 Genome informatics (General)
Cellular miRNAs play an important role in the regulation of gene expression in
eukaryotes. Recently, miRNAs have also been shown to be able to target and inhibit viral gene
expression. Computational predictions revealed earlier that the HIV-1 genome includes regions
that may be potentially targeted by human miRNAs. Here we report the functionality of predicted
miR-29a target site in the HIV-1 nef gene.
Ahluwalia, Jasmine K and Khan, Sohrab Zafar and Soni, Kartik and Rawat, Pratima and Gupta, Ankit and Hariharan, Manoj and Scaria, Vinod and Lalwani, Mukesh and Pillai, Beena and Mitra, Debashis and Brahmachari, Samir K. (2008) Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology, 5 (117).