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microRNAs in viral oncogenesis

IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New Delhi

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Title microRNAs in viral oncogenesis
Creator Scaria, Vinod
Jadhav, Vaibhav
Subject G1 Genome informatics (General)
Description MicroRNAs are a recently discovered class of small noncoding functional RNAs. These molecules mediate post-transcriptional regulation of gene expression in a sequence specific manner. MicroRNAs are now known to be key players in a variety of biological processes and have been shown to be deregulated in a number of cancers. The discovery of viral encoded microRNAs, especially from a family of oncogenic viruses, has attracted immense attention towards the possibility of microRNAs as critical modulators of viral oncogenesis. The host-virus crosstalk mediated by microRNAs, messenger RNAs and proteins, is complex and involves the different cellular regulatory layers. In this commentary, we describe models of microRNA mediated viral oncogenesis.
Date 2007-11-24
Type Article
Format application/pdf
Identifier http://openaccess.igib.res.in/90/1/1742%2D4690%2D4%2D82.pdf
Scaria, Vinod and Jadhav, Vaibhav (2007) microRNAs in viral oncogenesis. Retrovirology, 4 (82).
Relation http://openaccess.igib.res.in/90/