Causal prophylactic activity of a new 8-aminoquinoline derivative against plasmodium cynomolgi B in rhesus monkeys
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Puri, S K
Dutta, G P |
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| Date |
2009-09-08T08:39:03Z
2009-09-08T08:39:03Z 1990 |
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| Identifier |
Indian J Med Research (1990) 91,197-199
http://hdl.handle.net/123456789/503 |
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| Description |
A new 8-aminoquinoline derivative, N'-(3-acetyl-4-5-dihydro-2 furanyl)-N4-(6-methoxy-8-quinolinyl)1,4-pentanediamine, synthesized at CDRI, Lucknow, showed causal prophylactic activity at 3.16mg/kg x3 doses (on day -1,0 and+1)against sporozoite induced P.cynomelgi B infection in rhesus monkeys. Single dose of IOmg/kg of this compound on day 0 also prevented establishment of patent infection. Activity of the compound was comparable to that of primaquine (with causal prophylactic activity at 1.78mg/kg in three day test and at 10.0mg/kg in single dose test).
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1826945 bytes
application/pdf |
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| Language |
en
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| Title |
Causal prophylactic activity of a new 8-aminoquinoline derivative against plasmodium cynomolgi B in rhesus monkeys
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| Type |
Article
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