A versatile synthesis of dihydropyrimidinone c-nucleosides
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Mishra, R C
Katiyar, Diksha Tewari, Neetu Tripathi, R P |
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| Date |
2009-09-05T05:52:41Z
2009-09-05T05:52:41Z 2005 |
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| Identifier |
Nucleosides, Nucleotides & Nucleic Acids (2005), 24,15–35
http://hdl.handle.net/123456789/494 |
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| Description |
A versatile syntheses of N-aryl dihydropyrimidinone C-nucleosides (20-29) is described. Glycosyl amino esters (3-9), obtained by reductive arylation of glycosyl amino esters 1 and 2, on condensation with different isocyanates afforded respective ureidyl derivatives (10-19) in good to quantitative yields. The latter on cyclative amidation with a combination of DBU/ tetra butyl ammonium bromide/ 4Å MS gave the respective nucleosides (20-29) in good yields.
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| Format |
158198 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 6338
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| Title |
A versatile synthesis of dihydropyrimidinone c-nucleosides
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| Type |
Article
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