A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid
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| Creator |
Kaur, Rajbir
Khan, Sheema Chib, Renu Kaur, Tandeep Sharma, Parduman Raj Singh, Jaswant Shah, Bhahwal Ali Taneja, Subhash Chandra |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
Semi-synthetic analogues of b-boswellic acid (BA) and 11-keto-b-boswellic acid (KBA) were comparatively
evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several
biological end-points of the apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/184/1/10.1016j.ejmech.2011.01.061.pdf
Kaur, Rajbir and Khan, Sheema and Chib, Renu and Kaur, Tandeep and Sharma, Parduman Raj and Singh, Jaswant and Shah, Bhahwal Ali and Taneja, Subhash Chandra (2011) A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid. European Journal of Medicinal Chemistry, 46 (4). pp. 1356-1366. ISSN 02235234 |
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| Relation |
http://dx.doi.org/10.1016/j.ejmech.2011.01.061
http://iiim.csircentral.net/184/ |
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