4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens
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| Creator |
Ali, F.
Sangwan, P. L. Koul, S. Pandey, A. Bani, S. Abdullah, S. T. Sharma, P. R. Kitchlu, S. Khan, I. A. |
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| Subject |
Pharmacological Sciences
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| Description |
The present study focused on the antibacterial
and biofilm inhibitory potential of 4-epi-pimaric acid
isolated from aerial parts (stem and leaves) of Aralia
cachemirica L. (Araliaceae) against oral cavity pathogens.
4-epi-Pimaric acid exhibited minimum inhibitory concentration
(MIC) in the range of 4–16 μg/ml and minimum
bactericidal concentration (MBC) two- to four-folds higher
than MIC. There was significant inhibition in the biofilm
formation by Streptococcus mutans on the saliva coated
surface (P<0.05), and confocal microscopy revealed that
4-epi-pimaric acid inhibited the clumping and attachment of
S. mutans. At 8×MIC concentration, it significantly
prevented the pH drop and reduced S. mutans biofilms
(P<0.05). Increased propidium iodide staining and leakage
of 260- and 280-nm absorbing material by 4-epi-pimaric
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/179/1/10.1007s10096%2D011%2D1287%2Dx.pdf
Ali, F. and Sangwan, P. L. and Koul, S. and Pandey, A. and Bani, S. and Abdullah, S. T. and Sharma, P. R. and Kitchlu, S. and Khan, I. A. (2011) 4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens. European Journal of Clinical Microbiology & Infectious Diseases. ISSN 0934-9723 |
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| Relation |
http://dx.doi.org/10.1007/s10096-011-1287-x
http://iiim.csircentral.net/179/ |
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