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In vitro antileishmanial activity of Aloe vera leaf exudate: A potential herbal therapy in leishmaniasis

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Title In vitro antileishmanial activity of Aloe vera leaf exudate: A potential herbal therapy in leishmaniasis
 
Creator Dutta, A
Mandal, G
Mandal, C
Chatterjee, M
 
Subject Biochemistry & Molecular Biology
 
Description Aloe vera has wide spread use in health products, and despite several reports on the whole plant and inner gel, little work has been performed on the leaf exudate. Our aim was to evaluate the in vitro efficacy of Aloe vera leaf exudate (AVL) in leishmaniasis. Irrespective of the disease manifestation, promastigotes from strains responsible for cutaneous, mucocutaneous, and visceral leishmaniasis were susceptible to AVL and their IC50 ranged from 100 to 180 mu g/ml. In axenic amastigotes cultured from a L. donovani strain 2001 responsible for visceral leishmaniasis, the IC50 was 6.0 mu g/ml. AVL caused activation of host macrophages evident by an increased release of members of reactive oxygen species that was attenuated by preincubation with free radical scavengers. Collectively, our data indicates that AVL, via its direct leishmanicidal activity which can be further enhanced by activation of host macrophages, is an effective antileishmanial agent meriting further pharmacological investigations.
 
Publisher SPRINGERDORDRECHTVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
 
Date 2011-09-20T12:12:42Z
2011-09-20T12:12:42Z
2007
 
Type Proceedings Paper
 
Identifier GLYCOCONJUGATE JOURNAL
0282-0080
http://hdl.handle.net/123456789/14389
 
Language English