Genome-wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21
IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New Delhi
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| Title |
Genome-wide Association Study for Type 2 Diabetes in
Indians Identifies a New Susceptibility Locus at 2q21
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| Creator |
Tabassum, Rubina
Chauhan, Ganesh Dwivedi, Om Prakash Mahajan, Anubha Jaiswal, Alok Kaur, Ismeet Bandesh, Khushdeep Singh, Tejbir Mathai, Benan John Pandey, Yogesh Chidambaram, Manickam Sharma, Amitabh Chavali, Sreenivas Sengupta, Shantanu Ramkrishnan, Lakshmi Vankatesh, Pradeep Aggrawal, Sanjay K Ghosh, Saurabh Prabhakaran, Dorairaj Srinath, Reddy K Saxena, Madhukar Banerjee, Monisha Mathur, Sandeep Bhansali, Anil Shah, Viral N Madhu, Sri Venkata Marwaha, Raman K Basu, Analabha Scaria, Vinod McCarthy, Mark I DIAGRAM, DIAGRAM INDICO, INDICO Venkatesan, Radha Mohan, Viswanathan Tandon, Nikhil Bharadwaj, Dwaipayan |
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| Subject |
CH1 Chemical Biology
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| Description |
Indians undergoing socioeconomic and lifestyle transitions will
be maximally affected by epidemic of type 2 diabetes (T2D). We
conducted a two-stage genome-wide association study of T2D in
12,535 Indians, a less explored but high-risk group. We identified
a new type 2 diabetes–associated locus at 2q21, with the lead
signal being rs6723108 (odds ratio 1.31; P = 3.32 3 10
). Imputation
analysis re
212
) within TMEM163 that encodes a probable vesicular
transporter in nerve terminals. TMEM163 variants also showed
association with decreased fasting plasma insulin and homeostatic
model assessment of insulin resistance, indicating a plausible
effect through impaired insulin secretion. The 2q21 region
also harbors RAB3GAP1 and ACMSD; those are involved in neurologic
disorders. Forty-nine of 56 previously reported signals
showed consistency in direction with similar effect sizes in Indians
and previous studies, and 25 of them were also associated
(P , 0.05). Known loci and the newly identified 2q21 locus altogether
explained 7.65% variance in the risk of T2D in Indians. Our
study suggests that common susceptibility variants for T2D are
29 largely same across populations, but also reveals a populationspecific
locus and provides further insights into genetic architec-
ture and etiology of T2D.
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| Type |
Article
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://openaccess.igib.res.in/148/1/db12%2D0406.full.pdf
Tabassum, Rubina and Chauhan, Ganesh and Dwivedi, Om Prakash and Mahajan, Anubha and Jaiswal, Alok and Kaur, Ismeet and Bandesh, Khushdeep and Singh, Tejbir and Mathai, Benan John and Pandey, Yogesh and Chidambaram, Manickam and Sharma, Amitabh and Chavali, Sreenivas and Sengupta, Shantanu and Ramkrishnan, Lakshmi and Vankatesh, Pradeep and Aggrawal, Sanjay K and Ghosh, Saurabh and Prabhakaran, Dorairaj and Srinath, Reddy K and Saxena, Madhukar and Banerjee, Monisha and Mathur, Sandeep and Bhansali, Anil and Shah, Viral N and Madhu, Sri Venkata and Marwaha, Raman K and Basu, Analabha and Scaria, Vinod and McCarthy, Mark I and DIAGRAM, DIAGRAM and INDICO, INDICO and Venkatesan, Radha and Mohan, Viswanathan and Tandon, Nikhil and Bharadwaj, Dwaipayan Genome-wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21. Genome-wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21. |
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| Relation |
http://openaccess.igib.res.in/148/
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