An efficient entry to highly substituted chiral 2-oxopiperazines from α-amino acids via iodocyclization
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Jana, A K
Das, S K Panda, Gautam |
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| Date |
2013-02-05T09:28:14Z
2013-02-05T09:28:14Z 2012 |
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| Identifier |
Tetrahedron 2012, 68, (49), 10114–10121
http://hdl.handle.net/123456789/995 |
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| Description |
A short and stereoselective route for the synthesis of 2-oxopiperazines is presented starting from different naturally abundant α-amino acids. The key synthetic steps involved amide coupling, Wittig reaction, HWE olefination, aza-Michael reaction, iodocyclization. This new pathway involving first report of iodocyclization to construct chiral substituted 2-oxopiperazines furnished final compounds in good yields.
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| Format |
415412 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI communication no. 8327
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| Subject |
Oxopiperazines
Stereoselective Iodocyclization |
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| Title |
An efficient entry to highly substituted chiral 2-oxopiperazines from α-amino acids via iodocyclization
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| Type |
Article
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